Neuroimmunologie

Aktuelle wissenschaftliche Schwerpunkte sind:

  • die Anwendung und Weiterentwicklung neuer MR Methoden bei Multipler Sklerose: Q-space Analyse der langsamen Diffusionskomponenten, Arterial Spin Labelling (ASL) Perfusionsimaging, Whole BRAIN NAA Ganz-Hirn-NAA Messungen, Natrium MRT, Analysen der stimulierten Hirnaktivität und der Funktionellen Konnektivität bei nicht stimulierter Hirnaktivität und serielle Hirnvolumen MR-Analysen basierend auf Voxel-guided- Morphometry.
  • Untersuchungen zur Korrelation von klinischen und neuropsychologischen Markern mit strukturellen und funktionellen MR Charakteristika. Hierbei stehen Veränderungen akuter fokaler Läsionen, Veränderungen in der normal erscheinenden weissen Substanz wie auch chronische neurodegenerative Elemente der Pathologie im Focus.
  • Verbesserung der Bildgebung des Rückenmarks.
  • Einsatz der MRT in multizentrischen Studien als Selektionskriterium und zur Sicherheits- und Effizienzueberwachung.

 

Ausgewählte Publikationen

  • Bosnell R, Wegner C, Kincses ZT, Korteweg T, Agosta F, Ciccarelli O, De Stefano N, Gass A, Hirsch J, Johansen-Berg H, Kappos L, Barkhof F, Mancini L, Manfredonia F, Marino S, Miller DH, Montalban X, Palace J, Rocca M, Enzinger C, Ropele S, Rovira A, Smith S, Thompson A, Thornton J, Yousry T, Whitcher B, Filippi M, Matthews PM.Reproducibility of fMRI in the clinical setting: implications for trial designs. Neuroimage. 2008;42:603-10. Epub 2008 May 15.
  • M. Amann, J.G. Hirsch, A. Gass A serial fcMRI study in healthy individuals assessing the variability of functional connectivity measures: reduced interhemispheric connectivity in the motor network during continuous performance JMRI 2009;27:1347-59. Epub 2009 Jun 25
  • J. Linke, P. Kirsch, A.V. King, A. Gass, M.G. Hennerici, A. Bongers, M. Wessa Motivational orientation modulates the neural response to reward Neuroimage 2010;49:2618-25. Epub 2009 Sep 19.
  • Nicola De Stefano, Antonio Giorgio, Marco Battaglini, Marco Rovaris, Maria Pia 
    Sormani, Frederick Barkhof, Tijmen Korteweg, Christian Enzinger, Franz Fazekas, 
    Massimiliano Calabrese, Daria Dinacci, Gioacchino Tedeschi, Achim Gass, Xavier 
    Montalban, Alex Rovira, Alan Thompson, Giancarlo Comi, David H. Miller, and 
    Massimo Filippi Assessing Brain Atrophy Rates in a Large Population of Untreated Multiple Sclerosis Subtypes Neurology 2010;74:1868-76.
  • SJ BorgwardtH Egger, TE Nichols, P Loetscher, N Denier, P Kuster, S Traud, N Mueller-Lenke, Y Naegelin, A Gass, L Kappos,EW RadueK Bendfeldt Effect of immunmodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis – A longitudinal VBM study Brain Research 2010;1325:174-82. Epub 2010 Feb 16.
  • Ö. Yaldizli, R. Atefy, A. Gass, D. Sturm, S. Glassl, B. Tettenborn, N. Putzki Corpus Callosum Index and long-term disability in multiple sclerosis patients J Neurol 2010;257:1256-64. Epub 2010 Mar 3
  • Amann M, Dössegger LS, Penner IK, Hirsch JG, Raselli C, Calabrese P, Weier K, Radü EW, Kappos L, Gass A. Altered functional adaptation to attention and working memory tasks with increasing complexity in relapsing-remitting multiple sclerosis patients.Hum Brain Mapp. 2011;32:1704-19. epub 2010 Nov 12
  • J.J.G. Geurts, S.D. Roosendaal, M. Calabrese, O. Ciccarelli, F. Agosta, 
    A. Gass, B. Moraal, M.P. Wattjes, E. Huerga, D. Pareto, M.A. Rocca, D.T. Chard, 
    T.A. Yousry, B.M.J. Uitdehaag, F. Barkhof Proposed guidelines for in vivo MS cortical lesion scoring using double inversion recovery (DIR) MR imaging Neurology 2011;76:418-24. Epub 2011 Jan 5.
  • M. Griebe, A. Förster, M. Wessa*, C. Rossmanith, A. Gass, H. Bäzner, T. Sauer, K. Zohsel, C. Blahak, A.V. King*, J. Linke*, M.G. Hennerici, K. Szabo Loss of callosal fibre integrity in healthy elderly with age-related white matter changes (ARWMC) J Neurol 2011;258:1451–1459. Epub 2011 Feb 22.
  • Maeder P, Bracoud L, Chabriat H, Gass A, Michel P, Hennerici M. Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project. J Neurol. 2011;258:795-803.
  • Valsasina P, Rocca MA, Absinta M, Sormani MP, Mancini L, De Stefano N, Rovira A, Gass A, Enzinger C, Barkhof F, Wegner C, Matthews PM, Filippi M. A multicentre study of motor functional connectivity changes in patients with multiple sclerosis. Eur J Neurosci. 2011;33:1256-1263. Epub 2011 Mar 7.
  • K Bendfeldt,L Hoftstetter, P Kuster, S Traud, N Mueller-Lenke, Y Naegelin, L Kappos, A Gass,TE Nichols, F Barkhof, H Vrenken, SD Roosendaal, J JG Geurts, EW Radue, SJ Borgwardt 
    Longitudinal regional gray matter volume changes inrelapsing remitting multiple sclerosis-Comparison of MRI data from two different 1.5T scanners using voxel-based morphometry HBM 2012 May;33(5):1225-45. doi: 10.1002/hbm.21279. Epub 2011 Apr 29.
  • O Yaldizli, S Glass, D Sturm, A Papadopoulou, A Gass, B Tettenborn, N Putzki Fatigue and progression of corpus callosum atrophy in multiple sclerosis J Neurol 2011;258:2199-205. Epub 2011 May 19.
  • DJ Rigotti, A Gass, L Achtnichts, M Inglese, JS Babb, Y. Naegelin, J Hirsch, M Amann, L Kappos, O Gonen MultipleSclerosis Severity Scale and Whole-Brain N acetylaspartate Concentration for Patients’ AssessmentMultiple Sclerosis 2011:98-107. Epub 2011 Sep 15.
  • WE Wu, A Gass, L Glodzik,JS Babb, J Hirsch, M Sollberger, L Achtnichts, M Amann, AU Monsch, O Gonen Whole brainN-acetylaspartate in healthy adults shows life-long neuronal preservation Neurobiology of Aging 2012 Oct;33(10):2440-7. Epub 2012 Jan 14.
  • Douaud G, Jbabdi S, Behrens TE, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Kindlmann G, Matthews PM, Smith S. DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease. Neuroimage. 2011;55:880-90. Epub 2010 Dec 21.
  • AV King, J Linke, A Gass, MG Hennerici, Heike Tost, C Poupon Microstructure of a three-way anatomical network predicts individual differences in response inhibition: A tractography study Neuroimage2012;59:1949-59. Epub 2011 Sep 13.
  • Eisele P, K. Szabo A. Griebe, Rossmanith, Förster R. M.G. Hennerici A. Gass Reduced Diffusion in a Subset of Acute MS Lesions – A Serial Multiparametric MRI Study AJNR Am J Neuroradiol. 2012 May 10. [Epub ahead of print]
  • M Amann, L Achtnichts, JG Hirsch, Y Naegelin, J Gregori, K Weier, A Thöni, N Mueller-Lenke, EW Radü, M Günther, L Kappos, A Gass ASL Reveals InverseCorrelation of Cortical Perfusion with White Matter Lesion Volume in MS Multiple Sclerosis 2012 March 30 [Epub ahead of print]
  • K Weier, J Mazraeh, Y Naegelin, A Thoeni, J.G. Hirsch, T Fabbro, N Bruni, H Duyar, K Bendfeldt, EW Radue, Ludwig Kappos, A Gass Biplanar MRI for the Assessment of the Spinal Cord in Multiple Sclerosis Multiple Sclerosis2012 Apr 26. [Epub ahead of print]
  • Filli L, Hoftstetter, P Kuster, S Traud, N Mueller-Lenke, Y Naegelin, L Kappos, A Gass,TE Nichols, F Barkhof, H Vrenken, SD Roosendaal, J JG Geurts, EW Radue, SJ Borgwardt, K Bendfeldt Spatiotemporal Distribution of White Matter Lesions in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis Multiple Sclerosis 2012 Apr 11. [Epub ahead of print]
  • L Glodzik, WE Wu, A Gass, JS Babb, J Hirsch, M Sollberger, L Achtnichts, M Amann, AU Monsch, O Gonen The Whole-Brain N Acetylaspartate Correlates with Education in Normal Adults Psychiatry Research: Neuroimaging 2012 in press
  • T.A. Yousry, D. Pelletier, D. Cadavid, A. Gass, N.D. Richert, E-W Radue, M Filippi MRI pattern in natalizumab-associated progressive multifocal leukoencephalopathy Annals of Neurology, 2012;in press
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